
Increased throughput can lead to increased cost. Miniaturizing assays using high density microplates permits greater throughput with very significant reduction in reagent consumption and therefore costs and time.
| 96 Well | 384 Well | 384 Well LV | 1536 Well | 3456 Well | |
|---|---|---|---|---|---|
| Total well volume used (μL per well) | 200 | 50 | 20 | 7 | 2 |
| Compound or other special material (vol. in nL) | 100 | 25 | 10 | 4 | 1 |
| Special material cost | $10.00 |
$2.50 | $1.00 | $0.40 | $0.10 |
| Reagent cost | $0.20 |
$0.05 | $0.02 | $0.01 | $0.00 |
| Sample Cost = Reagent + Special | $10.20 |
$2.55 | $1.02 | $0.41 | $0.10 |
| Sample Cost per Plate | $979.20 |
$979.20 | $391.68 | $625.15 | $352.51 |
| Sample Cost per Screen | $10,200,000 |
$2,550,000 | $1,020,000 | $407,000 | $102,000 |
| Sample Cost per Year | $153,000,000 | $38,250,000 | $15,300,000 | $6,105,000 | $1,530,000 |
| No. Plates | 156,250 | 39,063 | 39,062.5 | 9,766 | 4,340 |
| Plate Pricing | $5.00 | $8.00 | $10.00 | $25.00 | $40.00 |
| Yearly Plate Cost | $781,250 | $312,500 | $390,625 | $244,141 | $173,611 |
| Totally Screening Consumable Cost | $153,781,250 | $38,562,500 | $15,690,625 | $6.349.141 | $1,703,611 |
| Total Wells | 15,000,000 | 15,000,000 | 15,000,000 | 15,000,000 | 15,000,000 |
| Cost per Well | $10.25 | $2.57 | $1.05 | $0.42 | $0.11 |